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MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus by Tracy A. Romano; Sam H. Ridgway; Vito Quaranta is a Environmental Science article available to read on EtoBox.

What is MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus about?

## Abstract The immune system of marine mammals is of comparative interest because of its adaptation to the aquatic environment. Little information, however, is available on its cellular and molecular components. Here, we used a cross‐reactive antibody to MHC class II molecules and an immunoglobulin‐specific antiserum for identifying these molecular species on lymphocytes of the bottlenosed dolphin, __Tursiops truncatus__. Limited structural analyses indicated that class II molecules and immunoglobulins of dolphin closely resemble those of other vertebrates. In the peripheral blood of most land mammals both class II and immunoglobulins are usually found on B but not T lymphocytes. Expression of immunoglobulins on dolphin peripheral blood lymphocytes suggests a ratio of B cells to T cells comparable to that of land mammals. However, unlike the majority of land mammals, virtually 100% of the peripheral T cells display pronounced expression of class II molecules, generally considered an indication of T cell activation. It is therefore possible that the physiology of T cell activation has unusual attributes in the dolphin. It is especially interesting that some land mammals, namely swi

Who reads MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus?

Author

Tracy A. Romano; Sam H. Ridgway; Vito Quaranta

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1992

Language

EN

Field

Environmental Science (Life Sciences)