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Hospital-diagnosed Infections Before Age 20 and Risk of a Subsequent Multiple Sclerosis Diagnosis by Yin Xu; Kelsi A Smith; Ayako Hiyoshi; Fredrik Piehl; Tomas Olsson; Scott Montgomery is a Neuroscience article available to read on EtoBox.

What is Hospital-diagnosed Infections Before Age 20 and Risk of a Subsequent Multiple Sclerosis Diagnosis about?

## Abstract The involvement of specific viral and bacterial infections as risk factors for multiple sclerosis has been studied extensively. However, whether this extends to infections in a broader sense is less clear and little is known about whether risk of a multiple sclerosis diagnosis is associated with other types and sites of infections such as the CNS. This study aims to assess if hospital-diagnosed infections by type and site before age 20 years are associated with risk of a subsequent multiple sclerosis diagnosis and whether this association is explained entirely by infectious mononucleosis, pneumonia, and CNS infections. Individuals born in Sweden between 1970 and 1994 were identified using the Swedish Total Population Register (n = 2 422 969). Multiple sclerosis diagnoses from age 20 years and hospital-diagnosed infections before age 20 years were identified using the Swedish National Patient Register. Risk of a multiple sclerosis diagnosis associated with various infections in adolescence (11–19 years) and earlier childhood (birth–10 years) was estimated using Cox regression, with adjustment for sex, parental socio-economic position, and infection type. None of the infe

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Author

Yin Xu; Kelsi A Smith; Ayako Hiyoshi; Fredrik Piehl; Tomas Olsson; Scott Montgomery

Publisher

Oxford University Press (OUP)

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)