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Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPα during oral cancer suppression by Kuo-Wei Chang; Pei-Shih Hung; I-Ying Lin; Chung-Ping Hou; Li-Kai Chen; Yin-Meng Tsai; Shu-Chun Lin is a Medicine article available to read on EtoBox.

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## Abstract Curcumin is a common food ingredient derived from the plant __Curcuma longa__ and is a potent drug against tumorigenesis. Both insulin‐like growth factor binding protein‐5 (IGFBP‐5) and CCAAT/enhancer‐binding protein α (C/EBPα) are suppressors of head and neck carcinogenesis. We identified curcumin as an inducer of IGFBP‐5 expression in multiple types of oral keratinocytes; furthermore, curcumin induces __IGFBP‐5__ promoter activity in SAS oral cancer cells. Promoter deletion mapping identified a region (nt −71 to nt −59 relative to the transcription start site) as containing a C/EBPα‐binding element that is indispensable for curcumin‐mediated IGFBP‐5 upregulation. Chromatin immunoprecipitation assays revealed that __in vivo__ binding of C/EBPα to this region was remarkably increased in the presence of curcumin. Curcumin increased nuclear C/EBPα expression and IGFBP‐5 expression through p38 activation and this was abrogated by SB203580 treatment. Furthermore, MKK6 expression activated p38 and C/EBPα, increasing IGFBP‐5 promoter activity and expression. Finally, curcumin‐induced IGFBP‐5 expression is associated with the suppression of xenograft tumorigenesis in mice due

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Author

Kuo-Wei Chang; Pei-Shih Hung; I-Ying Lin; Chung-Ping Hou; Li-Kai Chen; Yin-Meng Tsai; Shu-Chun Lin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2010

Language

EN

Field

Medicine (Health Sciences)