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A Novel Technique, Using Radioluminography, for the Measurement of Uniformity of Radiolabelled Antibody Distribution in a Colorectal Cancer Xenograft Model by Aiden A Flynn; Alan J Green; Geoffrey M Boxer; Joanne L Casey; R.Barbara Pedley; Richard H.J Begent is a Medicine article available to read on EtoBox.

What is A Novel Technique, Using Radioluminography, for the Measurement of Uniformity of Radiolabelled Antibody Distribution in a Colorectal Cancer Xenograft Model about?

Purpose: Radioimmunotherapy of cancer employs an antitumour antibody to carry a radionuclide selectively to deposits of cancer. Conventional dose estimates, based on the Medical Internal Radiation Dose (MIRD) formulation, assume uniform distribution of radiolabelled antitumour antibody within tissue source regions. This assumption has been tested by using a statistical model to predict the pixel value distribution obtained from the digitised radioluminographs of a known radioactive source. The model uses the statistical nature of the detection of radiation where any uniform source distribution can be expected to have a detected histogram of pixel counts that is normal or Gaussian. Therefore, any test for the degree of normality in the detected distribution is also a measure of the degree of uniformity in the source. Methods and Materials: Three statistical techniques have been used to test the normality of the histogram of pixel values produced from the antibody distribution in a tissue section. Kurtosis, skew, and Lilliefor's are tests for normality and have statistically defined critical values for a normal distribution. After administration of 125 I-labelled F(ab) 2 antibody to

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Author

Aiden A Flynn; Alan J Green; Geoffrey M Boxer; Joanne L Casey; R.Barbara Pedley; Richard H.J Begent

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1999

Language

EN

Field

Medicine (Health Sciences)