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Long-term Evolution of Estimated Glomerular Filtration Rate in Patients With Antiviral Treatment for Hepatitis C Virus Infection by Chen-Hua Liu; Jou-Wei Lin; Chun-Jen Liu; Tung-Hung Su; Jo-Hsuan Wu; Tai-Chung Tseng; Pei-Jer Chen; Jia-Horng Kao is a Medicine article available to read on EtoBox.

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## Background & aims: Data regarding the long-term evolution of estimated glomerular filtration rate (egfr) in patients receiving antiviral treatment for hepatitis c virus are limited. ## Methods: A total of 1987 patients with egfr ≥15 ml/min/1.73m who received interferon or direct-acting antiviral treatment were prospectively enrolled in this cohort study. the egfr was assessed biannually by the chronic kidney disease epidemiology collaboration equation from the time point of sustained virologic response (svr). multivariate generalized estimated equation was used to assess the association between the factors of interest and evolution of egfr following antiviral treatment. multivariate cox regression analysis was used to assess the relative risk of end-stage renal disease (esrd), defined as an egfr <15 ml/min/1.73m. ## Results: Patients who achieved svr (adjusted slope coefficient difference: 2.36 ml/min/1.73 m/year; 95% confidence interval [ci], 1.50 to 3.32; p < .001) were associated with egfr improvement, compared with those who did not achieve svr. among patients who achieved svr, the egfr evolution was comparable (adjusted slope coefficient difference: 0.31 ml/min/1.73m/year;

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Author

Chen-Hua Liu; Jou-Wei Lin; Chun-Jen Liu; Tung-Hung Su; Jo-Hsuan Wu; Tai-Chung Tseng; Pei-Jer Chen; Jia-Horng Kao

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)