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Can I read Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche on EtoBox?
Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche by Linda Beneforti; Erica Dander; Silvia Bresolin; Clara Bueno; Denise Acunzo; Mayla Bertagna; Anthony Ford; Bernhard Gentner; Geertruy te Kronnie; Patrizia Vergani; Pablo Menéndez; Andrea Biondi; Giovanna D’Amico; Chiara Palmi; Giovanni Cazzaniga is a Medicine article available to read on EtoBox.
What is Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche about?
## Summary ETV6‐RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration in childhood acute lymphoblastic leukemia (ALL). However, E/R is insufficient to cause overt leukemia since it generates a clinically silent pre‐leukemic clone which persists in the bone marrow but fails to out‐compete normal progenitors. Conversely, pre‐leukemic cells show increased susceptibility to transformation following additional genetic insults. Infections/inflammation are the most accredited triggers for mutations accumulation and leukemic transformation in E/R^+^ pre‐leukemic cells. However, precisely how E/R and inflammation interact in promoting leukemia is still poorly understood. Here we demonstrate that IL6/TNFα/ILβ pro‐inflammatory cytokines cooperate with BM‐MSC in promoting the emergence of E/R^+^ Ba/F3 over their normal counterparts by differentially affecting their proliferation and survival. Moreover, IL6/TNFα/ILβ‐stimulated BM‐MSC strongly attract E/R^+^ Ba/F3 in a CXCR2‐dependent manner. Interestingly, E/R‐expressing human CD34^+^IL7R^+^ progenitors, a putative population for leukemia initiation during development, were preserved in
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- Author
- Linda Beneforti; Erica Dander; Silvia Bresolin; Clara Bueno; Denise Acunzo; Mayla Bertagna; Anthony Ford; Bernhard Gentner; Geertruy te Kronnie; Patrizia Vergani; Pablo Menéndez; Andrea Biondi; Giovanna D’Amico; Chiara Palmi; Giovanni Cazzaniga
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)