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In-silico investigation of intratumoural magnetic hyperthermia for breast cancer therapy using FePt or FeCrNbB magnetic nanoparticles by Sreedhara Rao Gunakala; Victor M. Job; P.V.S.N. Murthy; P. Nagarani; H. Seetharaman; B.V. Chowdary is a Engineering article available to read on EtoBox.
What is In-silico investigation of intratumoural magnetic hyperthermia for breast cancer therapy using FePt or FeCrNbB magnetic nanoparticles about?
In this work, we conduct a numerical study on magnetic nanoparticle hyperthermia for the treatment of a breast tumour. The geometry of the problem is comprised of a deformed ellipsoidal tumour region, a healthy glandular tissue region, a fat tissue layer and a skin tissue layer. An aqueous suspension of magnetic nanoparticles (FeCrNbB or FePt) is directly injected into the breast tumour using a syringe. The perfusion of blood through the tissue regions is modelled using the Darcy-Brinkman-Forchheimer equation, and the shear-thinning behaviour of blood is described by the Carreau-Yasuda model. The transport and deposition of nanoparticles within the tissues, the temperature distribution during therapy, and the survival rates of healthy cells and cancer cells are also considered. The governing equations with their associated initial and boundary conditions are solved using the finite element method, and the solution algorithm developed in FreeFEM++ was validated against results from the existing literature. Subsequently, the influence of the nanoparticle solid volume fraction, injection time, and magnetic field amplitude and oscillation frequency on the velocity, temperature, nanopar
Who reads In-silico investigation of intratumoural magnetic hyperthermia for breast cancer therapy using FePt or FeCrNbB magnetic nanoparticles?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Sreedhara Rao Gunakala; Victor M. Job; P.V.S.N. Murthy; P. Nagarani; H. Seetharaman; B.V. Chowdary
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)