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Can I read Adenosine A3 receptors and viability of astrocytes on EtoBox?
Adenosine A3 receptors and viability of astrocytes by Maria P. Abbracchio; Stefania Ceruti; Roberta Brambilla; Daniela Barbieri; Alessandra Camurri; Claudio Franceschi; Anna Maria Giammarioli; Kenneth A. Jacobson; Flaminio Cattabeni; Walter Malorni is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Adenosine A3 receptors and viability of astrocytes about?
We investigated the role of the A 3 adenosine receptor in cells of the astroglial lineage (both rat primary astrocytes and human astrocytoma ADF cells) by means of the selective A 3 agonists N 6 -(3iodobenzyl)-adenosine-5¢-N-methyluronamide (IB-MECA) and CI-IB-MECA, and by utilizing the selective A 3 receptor antagonist MRS1191. Exposure of ADF cells to mM concentrations of either agonist resulted in reduction of cell number, likely due to cell death. In both rat astrocytes and human astrocytoma cells, at concentrations 2-3 orders of magnitude lower (which were not associated with cytotoxicity), these same agonists induced a marked reorganization of the cytoskeleton, with appearance of stress fibers and numerous cell protrusions. Functionally, these morphological changes were associated with cell protection, as demonstrated by a significant reduction of spontaneous apoptosis in A 3 agonist-treated cells. To confirm a role for the A 3 receptor in this effect, MRS1191 completely counteracted CI-IB-MECA-induced reduction of spontaneous apoptosis. In ADF cells, A 3 agonists also induced changes in the intracellular distribution of the anti-apoptotic protein Bcl-X L , which became local
Who reads Adenosine A3 receptors and viability of astrocytes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Maria P. Abbracchio; Stefania Ceruti; Roberta Brambilla; Daniela Barbieri; Alessandra Camurri; Claudio Franceschi; Anna Maria Giammarioli; Kenneth A. Jacobson; Flaminio Cattabeni; Walter Malorni
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)