Can I read The biological context of HIV-1 host interactions reveals subtle insights into a system hijack on EtoBox?

The biological context of HIV-1 host interactions reveals subtle insights into a system hijack by Jonathan E Dickerson; John W Pinney; David L Robertson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The biological context of HIV-1 host interactions reveals subtle insights into a system hijack about?

## Abstract ## Background In order to replicate, HIV, like all viruses, needs to invade a host cell and hijack it for its own use, a process that involves multiple protein interactions between virus and host. The HIV-1, Human Protein Interaction Database available at NCBI's website captures this information from the primary literature, containing over 2,500 unique interactions. We investigate the general properties and biological context of these interactions and, thus, explore the molecular specificity of the HIV-host perturbation. In particular, we investigate (i) whether HIV preferentially interacts with highly connected and 'central' proteins, (ii) known phenotypic properties of host proteins inferred from essentiality and disease-association data, and (iii) biological context (molecular function, processes and location) of the host proteins to identify attributes most strongly associated with specific HIV interactions. ## Results After correcting for ascertainment bias in the literature, we demonstrate a significantly greater propensity for HIV to interact with highly connected and central host proteins. Unexpectedly, we find there are no associations between HIV interaction a

Who reads The biological context of HIV-1 host interactions reveals subtle insights into a system hijack?

Author

Jonathan E Dickerson; John W Pinney; David L Robertson

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)