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Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats by Min Dong; Yao Luo; Yong Lan; Qinghua He; Lei Xu; Zuowei Pei is a Medicine article available to read on EtoBox.

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## Objective Hyperlipidemia is a risk factor for cardiac damage that can lead to many cardiovascular diseases. A recent study reported the cardioprotective effects of luteolin __in vitro__ and __in vivo__. In this study, we aimed to investigate the possible protective effects of luteolin against hyperlipidemia-induced cardiac damage in Sprague-Dawley (SD) rats. ## Methods Six-week-old male SD rats were randomly divided into five groups: a normal diet (ND) group; a high-fat diet (HFD) group; and three high-fat diet mixed with luteolin (HFD + LUT) groups, where in a luteolin dosage 50, 100, or 200 mg/kg/day was administered. All groups were fed their respective diets for 12 weeks. ## Results Left ventricular ejection fraction and fractional shortening (parameters of cardiac function) were lower in the HFD + LUT (100 mg/kg/day) group than in the HFD group. Metabolic parameters were lower in the HFD + LUT (100 mg/kg/day) group than in the HFD group. Collagen I, collagen III, and TGF-β expression levels were lower in the cardiac tissues of the HFD + LUT (100 mg/kg/day) group, compared to those of the HFD group. Expression of the profibrotic genes MMP2 and MMP9 was suppressed in the card

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Author

Min Dong; Yao Luo; Yong Lan; Qinghua He; Lei Xu; Zuowei Pei

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Physical Sciences)