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Selective Synthesis of Fluorinated Benzyl- or Phenylpyrimidines from the Heterocyclisation of α-Trifluoroacetylarylpropanenitriles by Hatice Berber; Catherine Mirand; Francis Derouin is a Chemistry article available to read on EtoBox.

What is Selective Synthesis of Fluorinated Benzyl- or Phenylpyrimidines from the Heterocyclisation of α-Trifluoroacetylarylpropanenitriles about?

Some 5-benzyl-6-trifluoromethyl-2,4-diaminopyrimidines analogous to trimethoprim and 6-aryl-5-trifluoroethyl-2,4-diaminopyrimidines analogous to pyrimethamine were prepared from the same synthons, trifluoromethylated b-ketonitriles. The heterocyclisation between enol ether of b-ketonitrile and guanidine leading to these compounds was studied. These fluorinated novel compounds were tested for their in vitro activity against Toxoplasma gondii, a widespread apicomplexan protozoa responsible for congenital toxoplasmosis and cerebral toxoplasmosis in immunocompromised patients.

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Author

Hatice Berber; Catherine Mirand; Francis Derouin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0022-1139)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)