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Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1,3-Dipolar Cycloaddition by Srijanani Bhaskar; Kyung-Ho Roh; Xuwei Jiang; Gregory L. Baker; Joerg Lahann is a Materials Science article available to read on EtoBox.

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## Abstract Precise nano‐ and microscale control of the architecture of biodegradable biomaterials is desirable for several biotechnological applications such as drug delivery, diagnostics, and medical imaging. Herein, we combine electrohydrodynamic co‐jetting and highly specific surface modification (via Huisgen 1,3‐dipolar cycloaddition) to prepare particles and fibers with spatioselective surface modification. We first prepared biphasic particles and fibers from commercial poly(lactide‐__co__‐glycolide) copolymers via electrohydrodynamic co‐jetting of two organic solutions loaded with fluorescent macromolecules and acetylene‐modified PLGA derivatives. (i) Spatially controlled reaction of poly[lactide‐__co__‐(propargyl glycolide)] with __O__‐(2‐aminoethyl)‐__O__′‐(2‐azidoethyl)heptaethylene glycol and (ii) subsequent conversion of the newly introduced amino groups with fluorescence probes resulted in particles and fibers with surface modification of one hemisphere only. magnified image

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Author

Srijanani Bhaskar; Kyung-Ho Roh; Xuwei Jiang; Gregory L. Baker; Joerg Lahann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1022-1336)

Published

2008

Language

EN

Field

Materials Science (Physical Sciences)