Can I read Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review on EtoBox?

Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review by Kai Siang Chan; Swetha Mohan; Vishal G Shelat is a Medicine article available to read on EtoBox.

What is Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review about?

Phosphate is an essential electrolyte for proper mineralisation of bone, buffering of urine, and diverse cellular actions. Hypophosphatemia (HP) is a clinical spectrum which range from asymptomatic to severe complications such as neuromuscular and pulmonary complications, or even death. Post-hepatectomy HP (PHH) has been reported to be 55.5%-100%. Post-hepatectomy, there is rapid uptake of phosphate and increased mitotic counts to aid in regeneration of residual liver. Concurrently, PHH may be due to increased urinary phosphorous from activation of matrix extracellular phosphoglycoprotein in the injured liver, which decreases phosphate influx into hepatocytes to sustain adenosine triphosphate synthesis. A literature review was performed on PubMed till January 2022. We included 8 studies which reported on impact of PHH on post-operative outcomes. In patients with diseased liver, PHH was reported to have either beneficial or deleterious effects on post-hepatectomy liver failure (PHLF), morbidity and/or mortality in various cohorts. In living donor hepatectomy, PHLF was higher in PHH. Benefits of correction of PHH with reduced post-operative complications have been shown. Correction o

Who reads Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review?

Author

Kai Siang Chan; Swetha Mohan; Vishal G Shelat

Publisher

Baishideng Publishing Group Inc.

Published

2022

Language

EN

Field

Medicine (Health Sciences)