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What is Nucleophilic Addition-Elimination of Acyls about?

Carboxylic acids and their derivatives undergo nucleophilic addition-elimination reactions at the acyl carbon. Acid chlorides react readily with loss of chloride ion. Esters, acids, and amides can also undergo these reactions but require protonation to generate a good leaving group like alcohol, water, or amine. The reactivity decreases in the order of acid chlorides > anhydrides > esters > acids > amides. Electron-withdrawing groups increase the acidity of carboxylic acids and their reactivity.

Author

Chandra

Language

EN