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A Comparative Study of Hydrocortisone Versus Deflazacort in Drug-resistant Epilepsy of Childhood by Salvatore Grosso; Mariangela Farnetani; Rosa Mostardini; Duccio Cordelli; Rosario Berardi; Paolo Balestri is a Medicine article available to read on EtoBox.

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Steroids are commonly used for the treatment of intractable epilepsy. Deflazacort has shown similar effects to prednisone, but with a less worrying adverse-effect profile. In this study, we first compared the efficacy, safety, and seizure relapse rate of deflazacort versus hydrocortisone in children affected by drug-resistant epilepsies. This was an open, non-blinded, randomized clinical study of 35 children affected by drugresistant epilepsies. The study lasted 12 months. Group 1 (16 patients) received hydrocortisone for 6 months; group 2 (19 patients) was treated with deflazacort for the entire study period. Drug efficacy and tolerability were evaluated after 6 months of therapy. Seizure relapse rates were evaluated 12 months after the start of the study. After 6 months of therapy, hydrocortisone was effective in 44% of patients (responders, with a decrease in seizure frequency of >50%). Deflazacort was effective in 47% of patients (P = 0.9). Adverse events occurred in 37% of patients using hydrocortisone and in none of those using deflazacort (P = 0.002). At the end of the study, seizure relapse rate resulted significantly higher in group 1 than in group 2 (P = 0.04). Hydrocorti

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Author

Salvatore Grosso; Mariangela Farnetani; Rosa Mostardini; Duccio Cordelli; Rosario Berardi; Paolo Balestri

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2008

Language

EN

Field

Medicine (Health Sciences)