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Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial by Hamed Shafiee; Farahnaz Riahipour; Ahmad Hormati; Sajjad Ahmadpour; Mohammad Amin Habibi; Mostafa Vahedian; Reza Aminnejad; Mohammad Saeidi is a Neuroscience article available to read on EtoBox.

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## Background: Endoscopy provides valuable diagnostic information and intervention therapies for gastroenterologists. Therefore, various drugs have been used to induce sedation in patients undergoing endoscopy, whereas none have been considered preferred by endoscopists. In the current study, we decided to use the combination of magnesium sulfate, ketamine, and their synergistic effects for creating partial analgesia to increase the satisfaction of endoscopists and patients. ## Methods: This study is a Double-Blind Randomized Clinical Trial that investigates the sedative effect of ketamine, magnesium sulfate, and propofol in endoscopy. Patients were selected from individuals over 12 years old and with American Society of Anesthesia (ASA) physical status I or II. The study was performed on 210 patients classified as ASA (I have no underlying disease) or II (with underlying controlled disease). The whole group was relieved of pain through sedation according to Ramsay criteria, satisfaction with the operation, duration, recovery, nausea and vomiting, hypotension, and decreased oxygen saturation were compared. ## Results: A total of 155 patients were enrolled in our study, including 51

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Author

Hamed Shafiee; Farahnaz Riahipour; Ahmad Hormati; Sajjad Ahmadpour; Mohammad Amin Habibi; Mostafa Vahedian; Reza Aminnejad; Mohammad Saeidi

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)