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Can I read Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin on EtoBox?
Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin by Karin Müller-Decker; Günther Reinerth; Peter Krieg; Regina Zimmermann; Helmut Heise; Christiane Bayerl; Friedrich Marks; Gerhard Fürstenberger is a Medicine article available to read on EtoBox.
What is Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin about?
Expression of prostaglandin-H-synthase (PGHS) isozymes was analyzed in 50 biopsies of normal human skin and of pre-malignant and malignant skin lesions, by means of quantitative RT-PCR, immunoprecipitation and Western blotting, as well as immunohistochemistry. Normal skin constitutively expressed PGHS-1 in all cell layers of the epidermis, in endothelial cells of small blood vessels and in sweat-gland epithelium. PGHS-2 expression was very low and restricted to a few keratinocytes of the interfollicular and follicular epidermis. Steady-state concentrations of PGHS-1 and PGHS-2 mRNA were similar in normal skin and in basal-cell carcinomas, but PGHS-1 mRNA was reduced and PGHS-2 mRNA was elevated in actinic keratoses, squamous-cell carcinomas and keratoacanthomas. PGHS-1 protein was detected in all tumor biopsies, being occasionally increased in basal-cell carcinomas. High amounts of PGHS-2 protein were found in actinic keratoses, squamous-cell carcinomas and keratoacanthomas, but not in basal-cell carcinomas. Four malignant melanomas included in this study contained PGHS-1 but no PGHS-2 protein. Immunohistochemical analysis of the biopsies identified keratinocytes, in addition to ce
Who reads Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Karin Müller-Decker; Günther Reinerth; Peter Krieg; Regina Zimmermann; Helmut Heise; Christiane Bayerl; Friedrich Marks; Gerhard Fürstenberger
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)