Can I read (309) Risk Factors for Primary Graft Dysfunction after Heart Transplantation - A Systematic Review and Meta-Analysis on EtoBox?
(309) Risk Factors for Primary Graft Dysfunction after Heart Transplantation - A Systematic Review and Meta-Analysis by M. Vervoorn; S. Kaffka Genaamd Dengler; J. Kernkamp; E. Ballan; M. Mishra; N. van der Kaaij is a Medicine article available to read on EtoBox.
What is (309) Risk Factors for Primary Graft Dysfunction after Heart Transplantation - A Systematic Review and Meta-Analysis about?
Purpose Primary graft dysfunction (PGD) is an important contributor to early mortality after heart transplantation (HTX). The International Society for Heart and Lung Transplantation (ISHLT) published a consensus definition of primary graft dysfunction in 2014. We conducted a systematic review and meta-analysis of published literature aimed at identifying risk factors for PGD according the ISHLT consensus definition. Methods Studies were identified using Medline and Embase and were included if published after the establishment of the consensus definition, the population consisted of adults receiving isolated HTX and outcome was specified as development of PGD according to the ISHLT consensus definition. PRISMA-guidelines were applied. Only risk factors identified with multivariate analysis were included and inserted into meta-analysis if reported in ≥2 studies. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using the inverse variance method with a DerSimonian and Laird random-effects model. Results A total of 29 studies were included. Significant heterogeneity was noted regarding severity of PGD and risk factor definition, limiting pooling of data for met
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- Author
- M. Vervoorn; S. Kaffka Genaamd Dengler; J. Kernkamp; E. Ballan; M. Mishra; N. van der Kaaij
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)