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Inter‐individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver by Z. E. Wilson; A. Rostami‐Hodjegan; J. L. Burn; A. Tooley; J Boyle; S. W. Ellis; G. T. Tucker is a Medicine article available to read on EtoBox.
What is Inter‐individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver about?
**Aims** To determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of human liver and their interindividual variability. **Methods** Triplicate liver samples were used to determine values of MPPGL (__n__ = 20) and HPGL (__n__ = 7) after accounting for the fractional loss of microsomal protein or hepatocytes during processing. Repeated measurements from each liver sample allowed the estimation of true interindividual variability in MPPGL and HPGL using ANOVA. **Results** The value of MPPGL ranged from 26 to 54 mg g^−1^ (mean~geo~= 33 mg g^−1^). The value of HPGL ranged from 65 to 185 × 10^6^ cells g^−1^ (mean~geo~= 107 × 10^6^ cells g^−1^). **Conclusions** There is significant interindividual variability in MPPGL, which has implications for the accurate extrapolation of __in vitro__ data on drug metabolism to predict __in vivo__ metabolic clearance.
Who reads Inter‐individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Z. E. Wilson; A. Rostami‐Hodjegan; J. L. Burn; A. Tooley; J Boyle; S. W. Ellis; G. T. Tucker
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)