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CD40L‐Induced IL‐12 Production is Further Enhanced by the Th2 Cytokines IL‐4 and IL‐13 by D. M. A. Bullens; A. Kasran; K. Thielemans; M. Bakkus; J. L. Ceuppens is a Immunology and Microbiology article available to read on EtoBox.

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Interaction of the CD40L (CD154) molecule on activated T cells with its receptor, CD40, on macrophages and dendritic cells (DC) provides a strong signal for interleukin (IL)‐12 production. As IL‐12 is the most important factor in driving Th precursor (Thp) cells into T(h)elper 1 cells, CD40–CD40L interactions strongly promote Th1 differentiation. Th2 cytokines (IL‐4, IL‐13, IL‐10) on the other hand, are known to inhibit Th1 differentiation, and to promote either directly or indirectly, Th2 differentiation. Inhibition of lipopolysaccharide (LPS)‐induced IL‐12 production by IL‐4, IL‐13 and IL‐10 is supposed to be one such mechanism. However, we here report that IL‐4 and IL‐13 enhance p70 IL‐12 production and p40 mRNA transcription by human monocytes when the latter are stimulated trough triggering of CD40. This effect on IL‐12 induction is most clear in the presence of interferon (IFN)‐γ, which upregulates CD40 expression. IL‐10 potently inhibits IL‐12 production. The increased IL‐12 production in the presence of IL‐4 and IL‐13 is however, not the indirect result of a reduction in IL‐10 production, but is most likely owing to a direct effect of IL‐4 and IL‐13. We conclude that IL‐4 a

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Author

D. M. A. Bullens; A. Kasran; K. Thielemans; M. Bakkus; J. L. Ceuppens

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

2001

Language

EN

Field

Immunology and Microbiology (Life Sciences)