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Ganoderma Lucidum Polysaccharides Improve Lipid Metabolism Against High-fat Diet-induced Dyslipidemia by Wenshuai Wang; Yaohan Zhang; Zhiying Wang; Jianjun Zhang; Le Jia is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Ganoderma Lucidum Polysaccharides Improve Lipid Metabolism Against High-fat Diet-induced Dyslipidemia about?

Ethnopharmacological relevance As a kind of traditional medicinal fungi, Ganoderma lucidum has been employed as folk medicine in China against multiple metabolic diseases on account of its superior bioactivities. Recently, accumulated reports have investigated the protective effects of G. lucidum polysaccharides (GLP) on ameliorating dyslipidemia. However, the specific mechanism by which GLP improves dyslipidemia is not completely clear. Aims of the study This study aimed to investigate the protective effects of GLP on high-fatdiet-induced hyperlipidemia and exploring its underlying mechanism. Materials and methods The GLP was successfully obtained from G. lucidum mycelium. The mice were conducted with high-fatdiet to establish the hyperlipidemia model. Biochemical determination, histological analysis, immunofluorescence, western blot and real-time qPCR were used to assess the alterations in high-fatdiet-treated mice after the GLP intervention. Results It was found that GLP administration significantly decreased body weight gain and the excessive lipid levels, and partly alleviated tissue injury. Oxidative stress and inflammations were efficiently ameliorated after the treatment of

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Author

Wenshuai Wang; Yaohan Zhang; Zhiying Wang; Jianjun Zhang; Le Jia

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)