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Rational Design of a Solvatochromic Fluorescent Uracil Analogue with a Dual‐Band Ratiometric Response Based on 3‐Hydroxychromone by Dmytro Dziuba; Iuliia A. Karpenko; Nicolas P. F. Barthes; Benoît Y. Michel; Andrey S. Klymchenko; Rachid Benhida; Alexander P. Demchenko; Yves Mély; Alain Burger is a Chemistry article available to read on EtoBox.
What is Rational Design of a Solvatochromic Fluorescent Uracil Analogue with a Dual‐Band Ratiometric Response Based on 3‐Hydroxychromone about?
## Abstract Fluorescent nucleoside analogues with strong and informative responses to their local environment are in urgent need for DNA research. In this work, the design, synthesis and investigation of a new solvatochromic ratiometric fluorophore compiled from 3‐hydroxychromones (3HCs) and uracil fragments are reported. 3HC dyes are a class of multi‐parametric, environment‐sensitive fluorophores providing a ratiometric response due to the presence of two well‐resolved bands in their emission spectra. The synthesized conjugate demonstrates not only the preservation but also the improvement of these properties. The absorption and fluorescence spectra are shifted to longer wavelengths together with an increase of brightness. Moreover, the two fluorescence bands are better resolved and provide ratiometric responses across a broader range of solvent polarities. To understand the photophysical properties of this new fluorophore, a series of model compounds were synthesized and comparatively investigated. The obtained data indicate that uracil and 3HC fragments of this derivative are coupled into an electronic conjugated system, which on excitation attains strong charge‐transfer charact
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- Author
- Dmytro Dziuba; Iuliia A. Karpenko; Nicolas P. F. Barthes; Benoît Y. Michel; Andrey S. Klymchenko; Rachid Benhida; Alexander P. Demchenko; Yves Mély; Alain Burger
- Publisher
- Wiley
- Published
- 2014
- Language
- EN
- Field
- Chemistry (Physical Sciences)