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This study demonstrates that RORgt-positive dendritic cells (DCs) are essential for the induction of peripheral regulatory T cells (pTregs) in response to oral antigens, as evidenced by a mouse model with a deletion of a regulatory element in the Rorc gene which resulted in reduced RORgt+ DCs and impaired oral tolerance. The findings indicate that RORgt+ DCs play a critical role in maintaining intestinal immune balance and preventing inappropriate immune responses to food antigens. The research highlights t

Author

Danish umar

Language

EN