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Can I read Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease on EtoBox?
Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease by Gunhild Waldemar; Serge Gauthier; Roy Jones; David Wilkinson; Jeffrey Cummings; Oscar Lopez; Richard Zhang; Yikang Xu; Yijun Sun; Sean Knox; Sharon Richardson; Joan Mackell is a Medicine article available to read on EtoBox.
What is Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease about?
To determine whether donepezil treatment (10 mg/day over 24 weeks) is associated with delayed emergence of apathy in patients with mild to moderate Alzheimer's disease (AD) and to explore relationships between donepezil's effects on apathy and other Neuropsychiatric Inventory (NPI)measured behavioural symptoms. Methods: Two randomised, double-blind, parallel-group, placebo-controlled studies that met prespecified criteria and were sufficiently similar to allow data pooling were derived from all donepezil AD clinical trials. Patients scoring from 10 to 26 on baseline Mini-Mental Status Examination were included. A clinical milestone for apathy and other NPI items was defined as the first emergence of a composite score (frequency  severity) !3. Differences in time to event (i.e. milestone) between donepezil-and placebo-treated groups were assessed using the Kaplan-Meier method and log-rank test. Shift tables were constructed to evaluate clinical milestone status for apathy and other NPI items at baseline and endpoint, and were analysed using the Cochran-Mantel-Haenszel (CMH) test, stratified by baseline status. Results: Of all NPI items, apathy had the highest proportion of subjects
Who reads Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gunhild Waldemar; Serge Gauthier; Roy Jones; David Wilkinson; Jeffrey Cummings; Oscar Lopez; Richard Zhang; Yikang Xu; Yijun Sun; Sean Knox; Sharon Richardson; Joan Mackell
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)