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Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study by Giovanna Russo; Vito Miraglia; Francesca Branciforte; Sofia Maria Rosaria Matarese; Marco Zecca; Gianni Bisogno; Emilia Parodi; Giovanni Amendola; Paola Giordano; Momcilo Jankovic; Annalisa Corti; Margherita Nardi; Piero Farruggia; Laura Battisti; Carlo Baronci; Giovanni Palazzi; Fabio Tucci; Stefania Ceppi; Bruno Nobili; Ugo Ramenghi; Domenico De Mattia; Lucia Notarangelo; the AIEOP‐ITP Study Group is a Medicine article available to read on EtoBox.

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## Abstract ## Background The eradication of __Helicobacter pylori__ has been associated with remission of immune thrombocytopenia (ITP) in approximately half of eradicated patients. Data on children are limited to small case series. ## Procedure Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for __H. pylori__ infection. Positive patients underwent standard triple therapy with amoxicillin, clarithromycin, and omeprazole. The eradication response was defined as follows: complete response, platelet (PLT) count ≥150 × 10^9^/L; partial response, PLT count of at least 50 × 10^9^/L; no response, PLT count <50 × 10^9^/L. ## Results Of 244 screened patients, 50 (20%) had __H. pylori__ infection, 37 of which received eradication therapy and completed follow‐up. Eradication was successful in 33/37 patients (89%). PLT recovery was demonstrated in 13/33 patients after eradication (39%), whereas spontaneous remission was observed in 17/166 (10%) __H. pylori__‐negative patients (__P__ < 0.005). Responders more often required second line eradication (9/13), whereas a second cycle was required in 3/20 non‐responders (__P__

Who reads Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study?

Author

Giovanna Russo; Vito Miraglia; Francesca Branciforte; Sofia Maria Rosaria Matarese; Marco Zecca; Gianni Bisogno; Emilia Parodi; Giovanni Amendola; Paola Giordano; Momcilo Jankovic; Annalisa Corti; Margherita Nardi; Piero Farruggia; Laura Battisti; Carlo Baronci; Giovanni Palazzi; Fabio Tucci; Stefania Ceppi; Bruno Nobili; Ugo Ramenghi; Domenico De Mattia; Lucia Notarangelo; the AIEOP‐ITP Study Group

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2010

Language

EN

Field

Medicine (Health Sciences)