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Effect of the alcohol extract of the seeds of Mucuna pruriens on free radicals and oxidative stress in albino rats by Yamini B. Tripathi; Anil K. Upadhyay is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract __In vitro__ and __in vivo__ studies were made with an alcohol extract of the seeds of __Mucuna pruriens__ (Fabaceae) to investigate its antioxidant property. __In vitro__ studies were carried out in rat liver homogenate to investigate the chemical interaction of various phytochemicals with different species of free radicals. The effect was also checked on iron‐induced lipid peroxidation, oxidation of GSH content, and its interaction with hydroxyl and superoxide radicals. There was no change on the rate of aerial oxidation of GSH content but it significantly inhibited FeSO~4~ induced lipid peroxidation. It also inhibited the specific chemical reactions induced by superoxides and hydroxyl radicals. The removal of these species was through direct chemical interaction. An __in vivo__ study on albino rats for 30 days showed no toxic effect up to a dose of 600 mg/kg body weight, on oral administration. There was no change in the level of TBA‐reactive substances, reduced glutathione content and SOD activity in the liver. The activity of serum GOT, GPT and alkaline phosphatase was also unchanged. Thus it could be concluded that the alcohol extract of the seeds of __M. pruriens
Who reads Effect of the alcohol extract of the seeds of Mucuna pruriens on free radicals and oxidative stress in albino rats?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yamini B. Tripathi; Anil K. Upadhyay
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)