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Can I read PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and meta-analysis on EtoBox?
PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and meta-analysis by Antonio Raffone; Antonio Travaglino; Gabriele Saccone; Martina Viggiani; Pierluigi Giampaolino; Luigi Insabato; Antonio Mollo; Giuseppe De Placido; Fulvio Zullo is a Medicine article available to read on EtoBox.
What is PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and meta-analysis about?
## Purpose: Rates of progression of endometrial hyperplasia (eh) to endometrial cancer (ec) are highly variable. among several prognostic markers, pten has been recommended by esmo-esgo-estro to identify premalignant eh. however, its prognostic accuracy is unclear. thus, we aimed to assess: (1) the association between pten loss in eh and risk of cancer, and (2) the prognostic accuracy of pten immunohistochemistry in eh. ## Methods: Electronic databases were searched from their inception to june 2018. all studies assessing pten immunohistochemistry in eh and the presence of ec on subsequent hysterectomy were included. odds ratio (or), sensitivity, specificity, positive and negative predictive value (ppv and npv), positive and negative likelihood ratio (lr + and lr-) and area under the curve (auc) on sroc curves were calculated with subgroup analysis (short/long-term; atypical/non-atypical eh). ## Results: Nine retrospective studies assessing 933 eh were included. pten loss in eh was significantly associated with increased risk of ec (or = 3.32, p = 0.001). the association was significant only on the short term ( < 1 year) (or = 3.45, p = 0.002) and in atypical eh (or = 1.89, p = 0.0
Who reads PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and meta-analysis?
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- Author
- Antonio Raffone; Antonio Travaglino; Gabriele Saccone; Martina Viggiani; Pierluigi Giampaolino; Luigi Insabato; Antonio Mollo; Giuseppe De Placido; Fulvio Zullo
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)