Opening book details…
Can I read Pimarane‐type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram‐positive Multidrug‐resistant Bacteria on EtoBox?
Pimarane‐type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram‐positive Multidrug‐resistant Bacteria by Thiago S. Porto; Marília R. Simão; Lucas Z. Carlos; Carlos H. G. Martins; Niege A. J. C. Furtado; Suraia Said; Nilton S. Arakawa; Raquel A. dos Santos; Rodrigo C. S. Veneziani; Sérgio R. Ambrósio is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Pimarane‐type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram‐positive Multidrug‐resistant Bacteria about?
The present study describes the antimicrobial activity of five pimarane‐type diterpenes obtained by fungal biotransformation against several nosocomial multidrug‐resistant bacteria. Among the investigated metabolites, __ent__‐8(14),15‐pimaradien‐3β‐ol was the most active compound, with very promising minimal inhibitory concentration values (between 8.0 and 25.0 μg mL^−1^). Time‐kill assays using this metabolite against __Staphylococcus aureus__ (HCRP180) revealed that this compound exerted its bactericidal effect within 24 h at all the evaluated concentrations (8.0, 16.0, and 24.0 μg mL^−1^). When this metabolite was associated with vancomycin at their minimal bactericidal concentration values, the resulting combination was able to drastically reduce the number of viable strains of __S__. __aureus__ within the first 6 h, compared with these chemicals alone. The checkerboard assays conducted against this microorganism did not evidence any synergistic effects when this same combination was employed. In conclusion, our results point out that __ent__‐8(14),15‐pimaradien‐3β‐ol is an important metabolite in the search for new effective antimicrobial agents. Copyright © 2012 John Wiley &
Who reads Pimarane‐type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram‐positive Multidrug‐resistant Bacteria?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Thiago S. Porto; Marília R. Simão; Lucas Z. Carlos; Carlos H. G. Martins; Niege A. J. C. Furtado; Suraia Said; Nilton S. Arakawa; Raquel A. dos Santos; Rodrigo C. S. Veneziani; Sérgio R. Ambrósio
- Publisher
- Wiley
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)