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Genotoxic Effects of a Particular Mixture of Acetamiprid and α‐Cypermethrin on Chromosome Aberration, Sister Chromatid Exchange, and Micronucleus Formation in Human Peripheral Blood Lymphocytes by Ayşe Yavuz Kocaman; Mehmet Topaktaş is a Environmental Science article available to read on EtoBox.
What is Genotoxic Effects of a Particular Mixture of Acetamiprid and α‐Cypermethrin on Chromosome Aberration, Sister Chromatid Exchange, and Micronucleus Formation in Human Peripheral Blood Lymphocytes about?
## Abstract The genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and α‐cypermethrin (α‐cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined __in vitro__ by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human peripheral lymphocytes were treated with 12.5 + 2.5, 15 + 5, 17.5 + 7.5, and 20 + 10 μg/mL of Acm+α‐cyp, respectively, for 24 and 48 h. The mixture of Acm+α‐cyp induced the CAs and SCEs at all concentrations and treatment times when compared with both the control and solvent control and these increases were concentration‐dependent in both treatment times. MN formation was significantly induced at 12.5 + 2.5, 15 + 5, 17.5 + 7.5, μg/mL of Acm+α‐cyp when compared with both controls although these increases were not concentration‐dependent. Binuclear cells could not be detected sufficiently in the highest concentration of the mixture (20 + 10 μg/mL) for both the 24‐ and 48‐h treatment times. Mitotic index (MI), proliferation index (PI) and nuclear division index (NDI) significantly decreased because of the cytotoxic and cytostatic effects of the mixture, at all concentr
Who reads Genotoxic Effects of a Particular Mixture of Acetamiprid and α‐Cypermethrin on Chromosome Aberration, Sister Chromatid Exchange, and Micronucleus Formation in Human Peripheral Blood Lymphocytes?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Ayşe Yavuz Kocaman; Mehmet Topaktaş
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)
- Published
- 2009
- Language
- EN
- Field
- Environmental Science (Physical Sciences)