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Zinc protoporphyrin levels, blood lead levels and neurocognitive deficits in Andean children with chronic lead exposure by S. Allen Counter; Leo H. Buchanan; Fernando Ortega is a Medicine article available to read on EtoBox.

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## Objectives: To investigate the relationship between blood lead (pbb), zinc protoporphyrin (zpp) levels and performance on a test of auditory memory in andean children and adolescents with chronic lead (pb) exposure. ## Design and methods: Pbb and zpp levels were measured in blood samples from 166 participants (aged 6-16 yrs.) exposed to pb in a local ceramic glazing cottage industry in ecuadorian villages. pbb levels and zpp/heme ratios were analyzed in relation to performance on the digit span subtest of the wechsler iv intelligence scale, a test of auditory memory. ## Results: Mean pbb level for the study group was 18.0 microg/dl (s.d.: 15.1; range: 3.0-86.0), and the mean zpp/heme ratio was 105.7 mumol/mol (s.d.: 100.9; range: 36.0-592.0). there was no significant difference in pbb and zpp levels between the 84 females and the 82 males. the mean digit span scale score (ds ss) for the study group was 6.81 (s.d.: 2.95; range: 1.0-17.0), which is below the average score of 10 for the test, with the females performing significantly better than males (t=2.435; p=0.01). regression analyses revealed statistically significant inverse associations between ds ss and pbb level (r=0.251,

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Author

S. Allen Counter; Leo H. Buchanan; Fernando Ortega

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2008

Language

EN

Field

Medicine (Health Sciences)