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Can I read Determination of Encainide and Its Metabolites by High-performance Liquid Chromatography on EtoBox?
Determination of Encainide and Its Metabolites by High-performance Liquid Chromatography by K. Selinger; J.C. Crawhall is a Chemistry article available to read on EtoBox.
What is Determination of Encainide and Its Metabolites by High-performance Liquid Chromatography about?
Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy-O-demethylencainide (MODE), N-demethylencainide (NDE) and bis-N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a mu Porasil column with ethanol-water-methanesulphonic acid as mobile phase was not able to separately measure NODE and NDE in plasma. A new method is described using a mu Bondapak Phenyl column with acetonitrile-phosphate buffer (0.05 M, pH 7.5) that yields satisfactory separation of ENC and its metabolites. NODE was not identified as a metabolite in 23 patients analysed.
Who reads Determination of Encainide and Its Metabolites by High-performance Liquid Chromatography?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- K. Selinger; J.C. Crawhall
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 1988
- Language
- EN
- Field
- Chemistry (Physical Sciences)