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Proteomic analysis reveals stage‐specific reprogramed metabolism for the primary breast cancer cell lines MGSO‐3 and MACL‐1 by Fabio Henrique Guimarães Braga; Diana Paola Gómez‐Mendoza; Rafael Pereira Lemos; Lucas Rodrigues‐Ribeiro; Brenda Raíssa‐Oliveira; Andréia Laura Prates Rodrigues; Vladimir Gorshkov; Frank Kjeldsen; Jader Santos Cruz; Thiago Verano‐Braga is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Proteomic analysis reveals stage‐specific reprogramed metabolism for the primary breast cancer cell lines MGSO‐3 and MACL‐1 about?
## Abstract Breast cancer is the most prevalent cancer in women worldwide. Its molecular subtypes are based on the presence/absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). MACL‐1 and MGSO‐3 are cell lines derived from primary tumor sites of patients diagnosed with luminal A subtype carcinoma (ER+/PR+/HER2−) and ductal carcinoma in situ (ER−/PR−/HER2+), respectively. However, these cell lines lost the expression of these markers over cell culturing, and both have triple‐negative phenotypes (ER−/PR−/HER2−), which has the poorest prognosis. Here, we sought to study the proteome signature of MGSO‐3 and MACL‐1, comparing them with the epithelial cell line MCF‐10A and the well‐established metastatic‐derived breast cancer cell line MDA‐MB‐231. Our results showed that proteins associated with the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) were upregulated in MGSO‐3 and MACL‐1 cells. These cell lines also showed upregulation of pro‐apoptotic proteins when compared with MDA‐MB‐231. The molecular differences highlighted in this study may clarify the molecular basis behind cancer cells functioning an
Who reads Proteomic analysis reveals stage‐specific reprogramed metabolism for the primary breast cancer cell lines MGSO‐3 and MACL‐1?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Fabio Henrique Guimarães Braga; Diana Paola Gómez‐Mendoza; Rafael Pereira Lemos; Lucas Rodrigues‐Ribeiro; Brenda Raíssa‐Oliveira; Andréia Laura Prates Rodrigues; Vladimir Gorshkov; Frank Kjeldsen; Jader Santos Cruz; Thiago Verano‐Braga
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)