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Can I read Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy on EtoBox?

Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy by Meliambro, Kristin (author);Li, Xuezhu (author);Salem, Fadi (author);Yi, Zhengzi (author);Sun, Zeguo (author);Chan, Lili (author);Chung, Miriam (author);Chancay, Jorge (author);Vy, Ha My T. (author);Nadkarni, Girish (author);Wong, Jenny S. (author);Fu, Jia (author);Lee, Kyung (author);Zhang, Weijia (author);He, John C. (author);Campbell, Kirk N. (author) is a Medicine article available to read on EtoBox.

What is Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy about?

Recent case reports suggest that coronavirus disease 2019 (COVID-19) is associated with collapsing glomerulopathy in African Americans with apolipoprotein L1 gene (__APOL1__) risk alleles; however, it is unclear whether disease pathogenesis is similar to HIV-associated nephropathy. RNA sequencing analysis of a kidney biopsy specimen from a patient with COVID-19–associated collapsing glomerulopathy and __APOL1__ risk alleles (G1/G1) revealed similar levels of __APOL1__ and angiotensin-converting enzyme 2 (__ACE2__) messenger RNA transcripts as compared with 12 control kidney samples downloaded from the GTEx (Genotype-Tissue Expression) Portal. Whole-genome sequencing of the COVID-19–associated collapsing glomerulopathy kidney sample identified 4 indel gene variants, 3 of which are of unknown significance with respect to chronic kidney disease and/or focal segmental glomerulosclerosis. Molecular profiling of the kidney demonstrated activation of COVID-19–associated cell injury pathways such as inflammation and coagulation. Evidence for direct severe acute respiratory syndrome coronavirus 2 infection of kidney cells was lacking, which is consistent with the findings of several recent

Who reads Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Meliambro, Kristin (author);Li, Xuezhu (author);Salem, Fadi (author);Yi, Zhengzi (author);Sun, Zeguo (author);Chan, Lili (author);Chung, Miriam (author);Chancay, Jorge (author);Vy, Ha My T. (author);Nadkarni, Girish (author);Wong, Jenny S. (author);Fu, Jia (author);Lee, Kyung (author);Zhang, Weijia (author);He, John C. (author);Campbell, Kirk N. (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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