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This document summarizes the UK Fast Forward trial which compared a hypofractionated whole breast radiotherapy schedule of 27Gy in 5 fractions or 26Gy in 5 fractions delivered over 1 week versus the standard 40Gy in 15 fractions over 3 weeks. The 5-year results found the 1-week schedules to be non-inferior to standard fractionation with regards to ipsilateral breast tumor relapse rates and normal tissue effects. While the 27Gy schedule resulted in more breast changes, the 26Gy schedule resulted in equivalen

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api-549064749

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