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In Vitro Uptake of a New Cholesteryl Carborane Ester Compound by Human Glioma Cell Lines by Gina Peacock; Richard Sidwell; Guangliang Pan; Svein ØIe; D. Robert Lu is a Chemistry article available to read on EtoBox.

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The cellular uptake and retention of a new cholesteryl carborane ester compound, cholesteryl 1,12-dicarba-closo-dodecaboranel-carboxylate (BCH), by two human glioma cell lines, glioblastoma multiforme SF-763 and SF-767, was evaluated. BCH, which is an extremely hydrophobic compound, was formulated into liposomes and incubated with two human glioma tumor cell lines and one human normal neuron cell line. The amount of BCH uptake by the cells was measured by high performance liquid chromatography. The effects of BCH concentration in the culture medium and the incubation time on the cellular uptake of BCH were studied. In addition, BCH uptake by tumor cells was examined in the presence and absence of lipoprotein in the culture medium. It was found that the amount of BCH taken by the glioma cell lines was much more (up to 14 times) than that by the normal neuron cell line. The cellular uptake of BCH was related to the amount of BCH in the medium as well as the incubation time. The cellular uptake of BCH by SF-763 and SF-767 cells after 16 h of incubation was 283.3 AE 38.9 and 264.0 AE 36.5 mg boron/g cells, respectively. The majority of BCH taken up in tumor cells was retained after the

Who reads In Vitro Uptake of a New Cholesteryl Carborane Ester Compound by Human Glioma Cell Lines?

Author

Gina Peacock; Richard Sidwell; Guangliang Pan; Svein ØIe; D. Robert Lu

Publisher

John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)