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(Carboxymethyl–Dextran)‐Modified Magnetic Nanoparticles Conjugated to Octreotide for MRI Applications by Guo‐Cheng Han; Yang Ouyang; Xue‐Ying Long; Yu Zhou; Meng Li; You‐Nian Liu; Heinz‐Bernhard Kraatz is a Chemistry article available to read on EtoBox.
What is (Carboxymethyl–Dextran)‐Modified Magnetic Nanoparticles Conjugated to Octreotide for MRI Applications about?
## Abstract The synthesis of (octreotide–carboxymethyl–dextran)‐modified magnetic nanoparticles (CMD‐MNPs), which were characterized by FT‐IR, AFM, TEM and XRD, and magnetic hysteresis, is described. Magnetic Resonance Imaging (MRI) experiments were performed on a 1.5 Tesla Magnetom Vision machine. The internalization of CMD‐MNPs‐OC into pancreatic cancer cells Bx‐PC3 and colon cancer cells HCT‐116 were investigated by transmission electron microscopy (TEM) and magnetic resonance imaging (MRI). The nanoparticles can be recognized specifically, via the somatostatin receptor, and which can be used as a __T__~2~ MRI contrast agent. TEM and MRI results show that somatostatin receptor can deliver OC‐modified MNPs into the cytoplasm of a cancer cell line.
Who reads (Carboxymethyl–Dextran)‐Modified Magnetic Nanoparticles Conjugated to Octreotide for MRI Applications?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Guo‐Cheng Han; Yang Ouyang; Xue‐Ying Long; Yu Zhou; Meng Li; You‐Nian Liu; Heinz‐Bernhard Kraatz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1434-1948)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)