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Variation in Effects of Chlorpromazine in Three Strains of Mice by John L. Fuller is a Neuroscience article available to read on EtoBox.
What is Variation in Effects of Chlorpromazine in Three Strains of Mice about?
Genetic factors have been implicated in the sensitivity of mice to ehlorpromazine, t{t;rF (1962) using a shuttle-box found that 90~ of C57BL/6J mice were completely inactive following a dose of ehlorpromazine which inactivated only 7 ~ of C3HeB/J mice. MEIE~ et al. (1963) using a different test found more prolonged depression of activity in C57BL/6 than in C3t{/An, a result consistent with HUFF'S finding. Variations in avoidance learning between these strains have been reported (KI~ and ~AVaO~ATIS 1956; ROYCE and CovI~GTO~ 1960; WINSTG~ 1963; COLLINS 1964). Strain C3H has generally been found to be more efficient in avoidance learning. It seemed of interest to determine whether genetic variations in avoidance learning and sensitivity to a tranquillizing drug were related. The more rapid learning of C3H mice might be attributed to a higher anxiety which in turn might make them more resistant to a drug like chlorpromazine. However, it is not certain that the locomotor activities which served as indices for effects of drugs in the two cited papers were induced by anxiety. In fact, ~etivity in a field is often taken to indicate less rather than more timidity. The observed differences i
Who reads Variation in Effects of Chlorpromazine in Three Strains of Mice?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- John L. Fuller
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)
- Published
- 1966
- Language
- EN
- Field
- Neuroscience (Life Sciences)