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Can I read The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration on EtoBox?

The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration by Yu, Yinghao (author);He, Alan Bohan (author);Liou, Michelle (author);Ou, Chenyin (author);Kozłowska, Anna (author);Chen, Pingwen (author);Huang, Andrew Chihwei (author) is a Medicine article available to read on EtoBox.

What is The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration about?

A growing body of studies has recently shown that abused drugs could simultaneously induce the paradoxical effect in reward and aversion to influence drug addiction. However, whether morphine induces reward and aversion, and which neural substrates are involved in morphine’s reward and aversion remains unclear. The present study first examined which doses of morphine can simultaneously produce reward in conditioned place preference (CPP) and aversion in conditioned taste aversion (CTA) in rats. Furthermore, the aversive dose of morphine was determined. Moreover, using the aversive dose of 10 mg/kg morphine tested plasma corticosterone (CORT) levels and examined which neural substrates were involved in the aversive morphine-induced CTA on conditioning, extinction, and reinstatement. Further, we analyzed c-Fos and p-ERK expression to demonstrate the paradoxical effect—reward and aversion and nonhomeostasis or disturbance by morphine-induced CTA. The results showed that a dose of more than 20 mg/kg morphine simultaneously induced reward in CPP and aversion in CTA. A dose of 10 mg/kg morphine only induced the aversive CTA, and it produced higher plasma CORT levels in conditioning and r

Who reads The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Yu, Yinghao (author);He, Alan Bohan (author);Liou, Michelle (author);Ou, Chenyin (author);Kozłowska, Anna (author);Chen, Pingwen (author);Huang, Andrew Chihwei (author)
Publisher
MDPI AG
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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