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Analysis of Models Involving Enzymatic Activities for the Occurrence of C→T Transition Mutations During Repeat-Induced Point Mutation (RIP) inNeurospora crassa by Mario R. Mautino; Alberto L. Rosa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Analysis of Models Involving Enzymatic Activities for the Occurrence of C→T Transition Mutations During Repeat-Induced Point Mutation (RIP) inNeurospora crassa about?

The phenomenon of repeat-induced point mutation (RIP), acting during the sexual phase of the model eukaryote Neurospora crassa, is considered to study the putative in vivo relationships existing between cellular levels of S-adenosylmethionine (SAM), cytosine methylation and the occurrence of C-->T transition mutations. We analyse the kinetic behaviour of the different enzymatic models proposed to explain the underlying mutagenic mechanisms of RIP. The dependence of the mutation rate on the cellular levels of the methyl group donor SAM was evaluated for the models of mutation catalysed by a DNA-cytosine deaminase, a DNA-(5-methylcytosine) deaminase, a DNA-(5-cytosine) methyltransferase, and for a model combining the activities of the last two enzymes. We propose that these models can be distinguished by studying the dependence of RIP on intracellular SAM levels.

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Author

Mario R. Mautino; Alberto L. Rosa

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)