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Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon by G. A. Petroianu; S. M. Nurulain; N. Nagelkerke; M Shafiullah; J. Kassa; K. Kuča is a Environmental Science article available to read on EtoBox.

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## Abstract There is a clear need for broad‐spectrum cholinesterase reactivators (active against a multitude of organophosphorus ester enzyme inhibitors) with a higher efficacy than pralidoxime. The purpose of the study was to quantify __in vivo__ the extent of oxime‐conferred protection, using methyl‐paraoxon [dimethyl p‐nitrophenyl phosphate; (methyl‐POX)] as a cholinesterase inhibitor. There were seven groups of six rats in each cycle of the experiment. Group 1 (G1) received 2 μmol methyl‐POX (≈ LD~50~), the other groups (G2‐7) received 2 μmol methyl‐POX + one of the six reactivators. The animals were monitored for 48 h and the time of mortality was recorded. The procedure was repeated six times. All substances were applied i.p. The experiments were repeated using 3 and 5 μmol methyl‐POX. Mortality data were compared and hazards ratios (relative risks) ranked using the Cox proportional hazards model with methyl‐POX dose and group (reactivator) as time‐independent covariables. The relative risk of death estimated by Cox analysis (95% CI) in oxime‐treated animals when compared with untreated animals, adjusted for methyl‐POX dose (high/low) was K‐27, 0.58 (0.42–0.80); K‐48, 0.60 (0

Who reads Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon?

Author

G. A. Petroianu; S. M. Nurulain; N. Nagelkerke; M Shafiullah; J. Kassa; K. Kuča

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2007

Language

EN

Field

Environmental Science (Physical Sciences)