Can I read Interference of Selected Flavonoid Aglycons in Platelet Aggregation Assays on EtoBox?

Interference of Selected Flavonoid Aglycons in Platelet Aggregation Assays by Mirza Bojić; Željko Debeljak; Marica- Medić-Šarić; Maja Tomičić is a Medicine article available to read on EtoBox.

What is Interference of Selected Flavonoid Aglycons in Platelet Aggregation Assays about?

## Background: Flavonoids are widely distributed across the plant kingdom and are therefore common ingredients in an everyday diet. some flavonoids have a potential to affect platelet aggregation; most often antiaggregatory effects of flavonoids are observed. the objective of this research was to evaluate the in vitro effect of a selected set of flavonoids on platelet aggregation in whole blood. ## Methods: The effect of five selected flavonoids (pinocembrin-7-methylether, epicatechin, hesperetin, 6-hydroxyflavone and 3,6-dihydroxyflavone) on platelet aggregation was studied in the citrated whole blood samples collected from 75 healthy volunteers. a multiplate(®) impedance analyzer and five different aggregation inducers (adp, arachidonic acid, collagen, ristocetin and trap-6) were utilized for the analysis of samples. ## Results: Minimal antiaggregatory concentrations (minaac) of flavonoids in individual tests were reported in the following ranges: 0.12-1.91 μm; 15.26-244.14 μm; 15.26-122.07 μm; and 0.06-15.26 μm for adp, collagen, trap-6 and ristocetin aggregation-inducers, respectively. when arachidonic acid was used for induction of platelet aggregation, a proaggregatory effect

Who reads Interference of Selected Flavonoid Aglycons in Platelet Aggregation Assays?

Author

Mirza Bojić; Željko Debeljak; Marica- Medić-Šarić; Maja Tomičić

Publisher

Walter de Gruyter GmbH

Published

2012

Language

EN

Field

Medicine (Health Sciences)