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Can I read A Novel Intra-ventricular Assist Device Enhances Cardiac Performance in Normal and Acutely Failing Isolated Porcine Hearts on EtoBox?
A Novel Intra-ventricular Assist Device Enhances Cardiac Performance in Normal and Acutely Failing Isolated Porcine Hearts by Daniël IM van Dort; Jos Thannhauser; Wim J Morshuis; Guillaume SC Geuzebroek; Dirk J Duncker is a Medicine article available to read on EtoBox.
What is A Novel Intra-ventricular Assist Device Enhances Cardiac Performance in Normal and Acutely Failing Isolated Porcine Hearts about?
## Background: We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total mechanical efficiency (TME) and assessed the effect of IVMP-support in acutely failing hearts. ## Methods: In 10 ex vivo beating porcine hearts, we studied hemodynamic parameters, as well as arterial and coronary venous oxygen content. We assessed cardiac power (CP), myocardial oxygen consumption (MVO~2~), and TME (CP divided by MVO~2~) under baseline conditions and during IVMP-support. Additionally, five isolated hearts were subjected to global hypoxia to investigate the effects of IVMP-support on CP under conditions of acute heart failure. ## Results: Under physiological conditions, baseline CP was 0.36 ± 0.10 W, which increased to 0.65 ± 0.16 W during IVMP-support (increase of 85% ± 24, p < 0.001). This was accompanied by an increase in MVO2 from 18.6 ± 6.2 ml/min at baseline, to 22.3 ± 5.0 ml/min during IVMP-support (+26 ± 31%, p = 0.005). As a result, TME (%) increased from 5.9 ± 1.2 to 8.8 ± 1.8 (50 ± 22% increase
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- Author
- Daniël IM van Dort; Jos Thannhauser; Wim J Morshuis; Guillaume SC Geuzebroek; Dirk J Duncker
- Publisher
- SAGE Publications
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)