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The Hormone Sensitive Lipase Gene in Familial Combined Hyperlipidemia and Insulin Resistance by J. Pihlajamäki; R. Valve; L. Karjalainen; P. Karhapää; I. Vauhkonen; M. Laakso is a Medicine article available to read on EtoBox.

What is The Hormone Sensitive Lipase Gene in Familial Combined Hyperlipidemia and Insulin Resistance about?

**Backround** Insulin resistance in the most common familial dyslipidemia, familial combined hyperlipidemia (FCHL), could be due to variations in the hormone sensitive lipase (HSL) gene. **Materials and methods** The coding region of the HSL gene was screened with the single strand conformation polymorphism analysis in probands of 27 FCHL families with 228 members. In addition, the C‐60G promoter substitution of the HSL gene was determined by the restriction fragment length polymorphism analysis in these subjects. **Results** No variants in the coding region of the HSL gene were found and the allele frequencies of the C‐60G promoter substitution and the silent variant (G3138A) in the 3′ untranslated region did not differ between 110 control subjects and 27 probands with FCHL. However, in control women the C‐60G substitution was associated with high body mass index [30·6 ± 0·9 kg m^−2^ (mean ± SD) in subjects with the C/G genotype and 24·8 ± 4·6 in subjects with the C/C genotype, __P__ = 0·012], and in control men with high rates of insulin‐stimulated whole body glucose uptake (70·1 ± 14·7 vs. 56·7 ± 14·2 μmol kg^−1^ min^−1^, __P__ = 0·014). In 228 FCHL family members this substitut

Who reads The Hormone Sensitive Lipase Gene in Familial Combined Hyperlipidemia and Insulin Resistance?

Author

J. Pihlajamäki; R. Valve; L. Karjalainen; P. Karhapää; I. Vauhkonen; M. Laakso

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)

Published

2001

Language

EN

Field

Medicine (Health Sciences)