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Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study by Nivriti Hurbans; Panjasaram Naidoo is a Medicine article available to read on EtoBox.

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## Background Dolutegravir is an integrase strand transfer inhibitor that has been recommended for use in first-line antiretroviral regimens by the World Health Organisation and is currently being rolled out globally. There has been safety concerns with dolutegravir which has caused concern about its use in the general population. Dolutegravir first-line regimens have been used in South Africa since early 2020. Therefore, the aim of the present study was to assess the efficacy, safety, and tolerability of first-line dolutegravir-based antiretrovirals amongst adults living with HIV in Durban, South Africa. ## Methods This was a mixed-methods study, which comprised a cross-sectional survey and longitudinal retrospective follow-up of medical records. The study was conducted between October 2020 and January 2022. Data were described using descriptive and summary statistics. Bivariate logistic regression was applied to socio-demographic and clinical variables and crude odds ratios with a 95% confidence interval was calculated. Pearson chi-square tests, paired sample T-tests, and cross-tabulations were performed on selected variables. ## Results A total of 461 participants were enrolled

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Author

Nivriti Hurbans; Panjasaram Naidoo

Publisher

BioMed Central

Published

2024

Language

EN

Field

Medicine (Health Sciences)