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She was a luminary in the field of Neonatal-Perinatal Medicine who distinguished herself as a scientist, leader, clinician, and teacher and whose contributions helped shape the direction of neonatal medicine over the past 5 decades. Maria was a renowned neonatologist, physiologist, and basic scientist whose research initially focused on investigating the effect of alterations of tissue oxygen delivery and more recently, on the mechanisms of hypoxic brain injury in the newborn. Her seminal work on the blood oxygen-hemoglobin equilibrium curve of preterm and term infants and how physiologic perturbations affect this curve formed the basis for defining critical tissue oxygen delivery in the newborn infant [1]. Although Maria respected the lung and its intricate functions, she became fascinated with blood as an oxygen-carrying tissue. Her subsequent investigations explored the molecular and biochemical mechanisms of brain injury in neonatal animal models, which led the future direction for prevention and attenuation of brain injury in newborn infants. However, it was her groundbreaking work in 1962 in assisted ventilation for terminal hyaline membrane disease that defined her research

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Publisher

S. Karger AG

Published

2020

Language

ES

Field

Medicine (Health Sciences)