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The study investigates the role of cathepsin S in the TAP-independent crosspresentation pathway of MHC class I molecules, highlighting its importance in generating peptides from exogenous antigens. It demonstrates that cathepsin S is essential for effective crosspresentation, as its absence leads to reduced immune responses to particulate and cell-associated antigens. The findings suggest that there are distinct proteolytic mechanisms involved in TAP-dependent and TAP-independent pathways, with cathepsin S

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Transport Is amazing

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