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Can I read Neurite-promoting Influences of Proliferating Schwann Cells and Target-tissues Are Not Prerequisite for Rapid Axonal Elongation After Nerve Crush on EtoBox?
Neurite-promoting Influences of Proliferating Schwann Cells and Target-tissues Are Not Prerequisite for Rapid Axonal Elongation After Nerve Crush by M. Bresjanac; J. Sketelj is a Neuroscience article available to read on EtoBox.
What is Neurite-promoting Influences of Proliferating Schwann Cells and Target-tissues Are Not Prerequisite for Rapid Axonal Elongation After Nerve Crush about?
An important role in peripheral nerve regeneration has been ascribed to humoral trophic and tropic agents arising from the nonneuronal cells in the distal nerve stump and the denervated targets. In order to estimate their contribution to axonal elongation after crush injury to the rat sciatic nerve, an in vivo model was designed in which local cellular and target-derived influences were eliminated by 1) freeze-thawing of a long nerve segment distal to the crush site and 2) cutting the nerve far distally to the crush site, but within the frozen-thawed segment, and deflecting the frozen-thawed nerve stump in the opposite direction from its natural course. The sensory and motor axon elongation rate was estimated from the results of the nerve pinch test and choline acetyltransferase distribution along the nerve segment distal to the crush. The elongation rate of regenerating axons in deflected nerve segments, either non-treated or frozenthawed, was close in magnitude to that obtained when target-derived influences were not eliminated. Neurotropism of axonal targets is therefore of little importance for axon elongation after nerve crush. In the absence of Schwann cells along the axonal
Who reads Neurite-promoting Influences of Proliferating Schwann Cells and Target-tissues Are Not Prerequisite for Rapid Axonal Elongation After Nerve Crush?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- M. Bresjanac; J. Sketelj
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1989
- Language
- EN
- Field
- Neuroscience (Life Sciences)