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High serum leptin levels in children with type 1 diabetes mellitus: contribution of age, BMI, pubertal development and metabolic status by Reyes Luna; Ricardo V. Garcia‐Mayor; Mary Lage; M. Amalia Andrade; Jesús Barreiro; Manuel Pombo; Carlos Dieguez; Felipe F. Casanueva is a Medicine article available to read on EtoBox.
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## OBJECTIVE Children with diabetes mellitus are prone to develop obesity and to experience a delay in onset of the pubertal process. In order to understand the role of leptin in these abnormalities, serum leptin levels were analysed in children with type 1 diabetes mellitus. ## SUBJECTS Twenty diabetic girls, 23 diabetic boys and 66 healthy children (selected from a reference population of 706 normal children), age‐, sex‐ and BMI‐matched with diabetic patients, were studied. ## MEASURMENTS Standing height, weight and BMI were determined in each child. Serum testosterone, oestradiol and leptin were measured by specific radioimmunoassays, and HBA1c by high performance liquid chromatography. ## RESULTS Both diabetic girls and boys showed higher leptin levels than the normative healthy population and a group of age‐, sex‐ and BMI‐matched normal children. In an age‐related analysis, leptin levels in diabetic girls rose from 7.4 ± 1.2 and 8.1 ± 2.1 μg/l for the 5–7.99 and 8–10.99 year groups, to 12.6 ± 2.4 μg/l for the 11–13.99 year group, and to 15.6 ± 4.0 μg/l in the 14–15.99 year group in parallel with body weight. Leptin concentrations were parallel but higher (__P__ < 0.05) than th
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- Author
- Reyes Luna; Ricardo V. Garcia‐Mayor; Mary Lage; M. Amalia Andrade; Jesús Barreiro; Manuel Pombo; Carlos Dieguez; Felipe F. Casanueva
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)