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Immunohistochemical patterns in rectal cancer: Application of tissue microarray with prognostic correlations by Eva Fernebro; Pär‐Ola Bendahl; Michael Dictor; Annette Persson; Mårten Fernö; Mef Nilbert is a Medicine article available to read on EtoBox.

What is Immunohistochemical patterns in rectal cancer: Application of tissue microarray with prognostic correlations about?

## Abstract We utilized the high‐throughput tissue microarray method to characterize immunohistochemical expression patterns with correlations to prognosis in rectal cancer. Immunostaining for the markers Ki‐67, Bcl‐2, p53, EGFR, E‐cadherin, β‐catenin, MLH1 and MSH2 was performed in 269 rectal cancers. Expression profiles were correlated to metastasis‐free survival. Immunostaining revealed frequent upregulation and/or aberrant staining patterns for several of the markers, but Ki‐67, p53, Bcl‐2 and EGFR did not show any correlation to prognosis. However, reduced membranous staining for β‐catenin (__p__ = 0.04), lack of cytoplasmic staining for β‐catenin (__p__ = 0.04), reduced membranous staining for E‐cadherin (__p__ = 0.02) and lack of cytoplasmic staining for E‐cadherin (__p__ = 0.02) correlated with metastatic disease. Multivariate analysis including the factors Dukes' stage and tumor differentiation grade demonstrated increased risk of metastatic disease in tumors with lack of cytoplasmic staining for β‐catenin (HR = 3.1, __p__ = 0.02), reduced membranous staining for β‐catenin (HR = 1.7, __p__ = 0.06) and reduced membranous staining for E‐cadherin (HR = 2.1, __p__ = 0.06). Los

Who reads Immunohistochemical patterns in rectal cancer: Application of tissue microarray with prognostic correlations?

Author

Eva Fernebro; Pär‐Ola Bendahl; Michael Dictor; Annette Persson; Mårten Fernö; Mef Nilbert

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)