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Skin immune cell characterization in juvenile and adult Göttingen Minipigs by Linda Allais; Elise Brisebard; Nicolas Ravas; Jean-Paul Briffaux; Marc Pallardy is a Environmental Science article available to read on EtoBox.

What is Skin immune cell characterization in juvenile and adult Göttingen Minipigs about?

The skin hosts a sophisticated immune system involving responses from both innate and adaptive immune cell populations. Swine skin is close to human skin by its structure, composition and function. In addition, the minipig is considered the model of choice in toxicology studies for drugs applied by the dermal route and developed for both the adult and paediatric indications. However, knowledge on the skin immune system in minipigs, particularly in Göttingen Minipigs, is still limited. The objective of our work was first to characterize the main skin immune populations (Langerhans cells, dermal dendritic cells, macrophages and T lymphocytes) in Göttingen Minipigs. In parallel, we compared the skin immune populations from healthy and immunocompromised piglets following oral treatment with cyclosporin A (CsA) at 10 mg/kg/day. We also explored other pathological conditions using a contact dermatitis model in minipigs challenged with a sensitizer, 2,4-dinitrochlorobenzene (DNCB). Langerhans cells and dermal MHCIICD163 cells were increased one month after oral treatment with CsA at 10 mg/kg/day. The contact dermatitis model in Göttingen Minipigs challenged by DNCB suggested migration of

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Author

Linda Allais; Elise Brisebard; Nicolas Ravas; Jean-Paul Briffaux; Marc Pallardy

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Environmental Science (Physical Sciences)